In 1966, three psychiatrists conducted a study that investigated how much the wives of men who had received LSD assisted treatment for alcoholism thought their husbands had changed.
In 1958, the Journal of Nervous and Mental Disease published a study that investigated the psychotherapeutic potential of lysergic acid diethylamide, better known as the psychedelic LSD.
A study published in 2009 found that stressful events that occurred during or immediately prior to the treatment of depression were associated with poor responses from antidepressant medication. Stressful events did not appear to cause this lack of responsiveness to treatment in psychotherapy, though.
Research published in the Journal of Counseling Psychology in 2009, found an association between depressive symptoms and reduced emotional disclosure.