Subscribe
The latest psychology and neuroscience discoveries.
My Account
  • Mental Health
  • Social Psychology
  • Cognitive Science
  • Psychopharmacology
No Result
View All Result
PsyPost
PsyPost
No Result
View All Result
Home Exclusive Cognitive Science

Brain noise found to nurture synapses

by Columbia University Medical Center
May 7, 2014
in Cognitive Science

[Follow PsyPost on LinkedIn to stay up-to-date on the latest developments in psychology and neuroscience]

Share on FacebookShare on Twitter

A study has shown that a long-overlooked form of neuron-to-neuron communication called miniature neurotransmission plays an essential role in the development of synapses, the regions where nerve impulses are transmitted and received. The findings, made in fruit flies, raise the possibility that abnormalities in miniature neurotransmission may contribute to neurodevelopmental diseases. The findings, by researchers at Columbia University Medical Center (CUMC), were published today in the online edition of the journal Neuron.

The primary way in which neurons communicate with each another is through “evoked neurotransmission.” This process begins when an electrical signal, or action potential, is transmitted along a long, cable-like extension of the neuron called an axon. Upon reaching the axon’s terminus, the signal triggers the release of chemicals called neurotransmitters across the synapse. Finally, the neurotransmitters bind to and activate receptors of the neuron on the other side of the synapse. Neurotransmitters are packaged together into vesicles, which are released by the hundreds, if not thousands, with each action potential. Evoked neurotransmission was first characterized in the 1950s by Sir Bernard Katz and two other researchers, who were awarded the 1970 Nobel Prize in Physiology or Medicine for their efforts.

“Dr. Katz also found that even without action potentials, lone vesicles are released now and then at the synapse,” said study leader Brian D. McCabe, PhD, assistant professor of pathology and cell biology and of neuroscience in the Motor Neuron Center. “These miniature events — or minis — have been found at every type of synapse that has been studied. However, since minis don’t induce neurons to fire, people assumed they were inconsequential, just background noise.”

Recent cell-culture studies, however, have suggested that minis do have some function and even their own regulatory mechanisms. “This led us to wonder why there would be such complicated mechanisms for regulating something that was just noise,” said Dr. McCabe.

To learn more about minis, the CUMC team devised new genetic tools to selectively up- or down-regulate evoked and miniature neurotransmission in fruit flies (a commonly used model organism for neuronal function and development). This was the first study to identify a unique role for minis in an animal model.

The researchers found that when both types of neurotransmission were blocked, synapse development was abnormal. However, inhibiting or stimulating evoked neurotransmission alone had no effect on synaptic development. “But when we blocked minis, synapses failed to develop,” said Dr. McCabe, “and when we stimulated the release of more minis, synapses got bigger.”

The study also showed that minis regulate synapse development by activating a signaling pathway in neurons involving Trio and Rac1 proteins in presynaptic neurons. These proteins are also found in humans.

It remains to be seen exactly how minis are exerting their effects. “Parallel communication occurs in computer networks,” Dr. McCabe said. “Computers communicate primarily by sending bursts of data bundled into packets. But individual computers also send out pings, or tiny electronic queries, to determine if there is a connection to other computers. Similarly, neurons may be using minis to ping connected neurons, saying in effect, ‘We are connected and I am ready to communicate.'”

The researchers are currently looking into whether minis have a functional role in the mature nervous system. If so, it’s possible that defects in minis could contribute to neurodegenerative disease.

ShareTweetSendScanShareSharePinSend
Previous Post

Musical training increases blood flow in the brain

Next Post

Army drug users twice as likely to use synthetic marijuana as regular marijuana

STAY CONNECTED

TRENDING

New psychology research shows how narcissistic tendencies influence perceptions of intellectual humility

Brain stimulation technique combined with cognitive training reduces ADHD symptoms in children

Psychedelic mushrooms and quiet quitting: Psilocybin use tied to working fewer overtime hours

Male weightlifters who use steroids are more prone to psychopathology than those who do not

Mindfulness study: Practicing self-compassion reduces impulse buying

Four distinct trajectories of psychopathic traits identified among youth in the legal system

RECENT

2016 election study uncovers surprising unconscious memory shifts among voters

New study highlights psilocybin’s promise for major depressive disorder treatment

Neuroimaging study reveals hate speech dulls brain’s empathy responses

Most Americans think that other people view pornography more often than they do, study finds

Pandemic lockdowns amplified smartphone mimicry, study reveals

Brain stimulation technique combined with cognitive training reduces ADHD symptoms in children

Mindfulness study: Practicing self-compassion reduces impulse buying

Male weightlifters who use steroids are more prone to psychopathology than those who do not

Currently Playing

New psychology research shows how narcissistic tendencies influence perceptions of intellectual humility

New psychology research shows how narcissistic tendencies influence perceptions of intellectual humility

New psychology research shows how narcissistic tendencies influence perceptions of intellectual humility

Narcissism
Unintended pregnancies take a toll on the mental health of new fathers

Unintended pregnancies take a toll on the mental health of new fathers

Mental Health
New study provides insight into the psychological core of dark personality traits

Four distinct trajectories of psychopathic traits identified among youth in the legal system

Psychopathy
Social working memory abnormalities may be a neurocognitive mechanism underlying poorer social connection in PTSD

Exposure to wood smoke leads to complex and long-lasting neuroinflammatory and neurometabolomic alterations

Mental Health
People who were better supervised by parents as early adolescents tend to have higher earnings as adults

People who were better supervised by parents as early adolescents tend to have higher earnings as adults

Business
People who consume more ultra-processed foods are more likely to experience psychological distress later in life

People who consume more ultra-processed foods are more likely to experience psychological distress later in life

Mental Health
  • Cognitive Science
  • COVID-19
  • Mental Health
  • Social Psychology
  • Drug Research
  • Conspiracy Theories
  • Meditation
  • Psychology of Religion
  • Aviation Psychology and Human Factors
  • Relationships and Sexual Health
  • Evolutionary Psychology
  • Neuroimaging
  • Psychedelic Drugs
  • Dark Triad
  • Political Psychology

About

PsyPost is a psychology and neuroscience news website dedicated to reporting the latest research on human behavior, cognition, and society. (READ MORE...)

  • Contact us
  • Disclaimer
  • Privacy policy
  • Terms and Conditions
Subscribe
  • My Account
  • Cognitive Science Research
  • Mental Health Research
  • Social Psychology Research
  • Drug Research
  • Relationship Research
  • About PsyPost
  • Contact
  • Privacy Policy

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In

Add New Playlist