Subscribe
The latest psychology and neuroscience discoveries.
My Account
  • Mental Health
  • Social Psychology
  • Cognitive Science
  • Psychopharmacology
No Result
View All Result
PsyPost
PsyPost
No Result
View All Result
Home Exclusive Psychopharmacology

Stroke-like brain damage is reduced in mice injected with omega-3s

by Columbia University Medical Center
August 22, 2016
in Psychopharmacology
Photo credit: NEI

Photo credit: NEI

[Subscribe to PsyPost on YouTube to stay up-to-date on the latest developments in psychology and neuroscience]

Share on FacebookShare on Twitter

Researchers from Columbia University Medical Center (CUMC) found that omega-3 fatty acids reduced brain damage in a neonatal mouse model of stroke.

Findings from the study were published recently in PLOS ONE.

The researchers treated 10-day-old mice that had incurred hypoxic-ischemic brain injury (caused by a decrease in blood flow and oxygen to the brain, as occurs during a stroke) with a fat emulsion containing either DHA or EPA–omega-3 fatty acids that are found in certain foods and in supplements. The researchers evaluated the mice’s neurological function 24 hours and 8 to 9 weeks after the brain injury.

EPA and DHA are bioactive omega-3 fatty acids that are found in oils extracted from cold-water fish. The CUMC researchers and other scientists have shown that these fish-oil fatty acids protect organs and cells in numerous ways after oxygen deprivation, reducing inflammation and cell death.

At 24 hours, mice treated with DHA, but not EPA, had a significant reduction in brain injury. In the following weeks, the DHA group also had significantly better results in multiple brain functions compared to the EPA-treated mice and untreated (control) mice.

The researchers also discovered that these mice had increased concentrations of DHA in their brain mitochondria, energy-producing structures in cells that can be injured by free radicals when blood flow is restored to the brain after a stroke. This process, known as reperfusion injury, is a common cause of brain damage following the oxygen and nutrient deprivation that occurs after a stroke.

“Our findings suggest that injecting the omega-3 fatty acid DHA after a stroke-like event has the ability to protect brain mitochondria against the damaging effects of free radicals,” said senior co-author, Vadim S. Ten, MD, PhD, associate professor of pediatrics at CUMC.

Interruption of blood flow and oxygen supply to the brain during or shortly after birth is a major cause of brain damage in newborns, causing life-long neurological impairments in more than 25 percent of those affected. Many of the pathways involved in this type of brain damage are similar to those in an adult stroke.

“Clinical trials are needed to determine if administering lipid emulsions containing DHA shortly after a stroke-like brain injury offers the same neuroprotective effects in babies and adults, as seen in mice. If successful, such trials could lead to the development of a novel therapy for stroke in newborns, children, and adults, addressing a major medical need,” said senior co-author Richard J. Deckelbaum, MD, CM, the Robert R. Williams Professor of Nutrition (in Pediatrics) and Professor of Epidemiology and director of the Institute of Nutrition at CUMC.

ShareTweetSendScanShareSharePinSend

NEWSLETTER SIGN-UP

STAY CONNECTED

TRENDING

One in four people may experience estrangement from a sibling in adulthood, study finds

Buzzing the brain with electricity can boost the willingness to engage in mental effort

Study links deviations in circadian rhythm patterns to psychiatric problems in adolescents

Study finds that poor sleep quality increases aggression, possibly by affecting emotional cognition

Virtual reality can inoculate people against the allure of alternative romantic partners, study finds

A history of intermittent fasting is associated with increased disordered eating behaviors

RECENT

Many self-identified heterosexuals report feeling attracted toward individuals of the same sex, study finds

Two “dark” personality traits help explain the link between childhood adversity and suicide risk

People are more inclined to get COVID-19 booster after reading tweets that target regret, study finds

Study links deviations in circadian rhythm patterns to psychiatric problems in adolescents

False confidence: Watching a simple video increases people’s belief in their own ability to land a plane

A history of intermittent fasting is associated with increased disordered eating behaviors

Psychologists developed a new measure of sexual anxiety sensitivity. It predicts some important sex-related outcomes.

Virtual reality can inoculate people against the allure of alternative romantic partners, study finds

Currently Playing

Individuals with dark personality traits are less oriented towards long-term mating strategies

Disclosing victim status reduces online dating matches regardless of race or sex

Individuals with dark personality traits are less oriented towards long-term mating strategies

Dark Triad
Longitudinal study examines the effects of adversity on wise reasoning

New study examines the psychological mechanisms underlying Solomon’s paradox

Social Psychology
Engaging in religious practice, even if you don’t believe, may increase your capacity to delay gratification

Engaging in religious practice, even if you don’t believe, may increase your capacity to delay gratification

Cognitive Science
New study sheds light on how three distinct types of first impressions predict subsequent dating outcomes

New study sheds light on how three distinct types of first impressions predict subsequent dating outcomes

Relationships and Sexual Health
A single, moderate dose of psilocybin reduces depressive symptoms for at least two weeks, controlled study finds

A single, moderate dose of psilocybin reduces depressive symptoms for at least two weeks, controlled study finds

Depression
Study identifies factors that influence the link between men’s body esteem and their ability to enjoy their sexuality

Study identifies factors that influence the link between men’s body esteem and their ability to enjoy their sexuality

Mental Health
  • Cognitive Science
  • COVID-19
  • Mental Health
  • Social Psychology
  • Drug Research
  • Conspiracy Theories
  • Meditation
  • Psychology of Religion
  • Aviation Psychology and Human Factors
  • Relationships and Sexual Health
  • Evolutionary Psychology
  • Neuroimaging
  • Psychedelic Drugs
  • Dark Triad
  • Political Psychology

About

PsyPost is a psychology and neuroscience news website dedicated to reporting the latest research on human behavior, cognition, and society. (READ MORE...)

  • Contact us
  • Privacy policy

Subscribe
  • My Account
  • Cognitive Science Research
  • Mental Health Research
  • Social Psychology Research
  • About PsyPost
    • Contact us
  • Privacy policy

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In

Add New Playlist

This website uses cookies. By continuing to use this website you are giving consent to cookies being used.