Use of cigarettes, alcohol, and abuse of prescription pain relievers among teens has declined since 2013 while marijuana use rates...

Details of the role of glutamate, the brain’s excitatory chemical, in a drug reward pathway have been identified for the...

A moderate dose of MDMA, commonly known as Ecstasy or Molly, that is typically nonfatal in cool, quiet environments can be...

People with severe mental illness such as schizophrenia or bipolar disorder have a higher risk for substance use, especially cigarette...

A study using mice provides insight into how a specific receptor subtype in the brain could play a role in...

An analysis of national prescribing patterns shows that more than half of patients who received an opioid prescription in 2009...

Fueled by increases in marijuana use, the rate of eighth-graders saying they have used an illicit drug in the past...

A regulatory protein best known for its role in a rare genetic brain disorder also may play a critical role...

Normal individuals who scored high on a measure of impulsive/antisocial traits display a hypersensitive brain reward system, according to a...

Nicotine withdrawal is a major reason why smokers have trouble quitting. While it is well-known that nicotine exerts its rewarding...

Children of drug abusers are at high risk for a wide-range of negative outcomes, including developmental and cognitive disabilities and...

Addiction and bipolar disorder are commonly co-occurring disorders, with up to 60% of individuals with bipolar disorder experiencing some form...

Some of the same brain mechanisms that fuel drug addiction in humans accompany the emergence of compulsive eating behaviors and...

Researchers have identified a key epigenetic mechanism in the brain that helps explain cocaine's addictiveness, according to research funded by...

Immunization with an experimental anti-cocaine vaccine resulted in a substantial reduction in cocaine use in 38 percent of vaccinated patients...