Subscribe
The latest psychology and neuroscience discoveries.
My Account
  • Mental Health
  • Social Psychology
  • Cognitive Science
  • Psychopharmacology
No Result
View All Result
PsyPost
PsyPost
No Result
View All Result
Home Exclusive Psychopharmacology Psychedelic Drugs Ayahuasca

New research identifies the most common physical and psychological side-effects of ayahuasca

by Colin Davidson
November 28, 2022
in Ayahuasca

[Subscribe to PsyPost on YouTube to stay up-to-date on the latest developments in psychology and neuroscience]

Share on FacebookShare on Twitter

Psychedelic drugs are experiencing something of a renaissance. It’s no longer a case of turning on, tuning in and dropping out, as the hippy mantra went in the 1960s. Tripping – whether on magic mushrooms, LSD or psychedelic toads – is now part of the global wellness industry. It’s a way to “find yourself” or deal with a mental health or spiritual crisis.

A psychoactive brew is also part of the mix, but perhaps for the more dedicated “psychonaut”. Because the effects are quite extreme, westerners who take ayahuasca usually do so in ceremonies led by a shaman known as an ayahuasquero or curandero. These ceremonies have been covered in Netflix shows such as (Un)Well.

Ayahuasca is a traditional South American drink used in religious ceremonies. It can be made in a wide variety of ways, but typically, components of two plants – Banisteriopsis caapi vines and the leaves of the chacruna bush – are combined to produce a bitter “tea” that is drunk during the ceremony.

One component is an LSD-like drug called DMT. The other is a monoamine oxidase inhibitor (MAOI), a chemical that prevents the metabolism (breakdown) of the DMT. A DMT “trip” usually lasts 35 to 45 minutes, but the MAOI makes it last much longer (around four hours).

Ayahuasca has been studied to determine if it can help with a variety of mental health issues, such as depression, anxiety or addiction, and many studies report positive effects. However, few studies have focused on the side-effects, and these studies are often small with participants only from South America.

A new study, published in the journal PLOS Global Public Health, has sought to remedy this gap in the knowledge. Using an online questionnaire, the researchers sought to examine the side-effects of ayahuasca in a much larger and more geographically diverse population.

The study ran from 2017-19 and over 10,000 respondents from more than 50 countries took part. Although most of the respondents came from Brazil (47%), significant numbers came from Europe (24%) and North America (15%).

The most common physical side-effects were nausea and vomiting (62% of respondents reported this), headache (17%) and abdominal pain (13%). Two per cent of participants needed medical attention for these physical issues. Mental health side-effects were also common: 42% reported “emotional-cognitive” side-effects (such as having nightmares or disturbed thoughts), and 38% reported altered perception.

The physical side-effects are most commonly found in older people and in people with higher lifetime use of ayahuasca. They were also more common in those with existing health conditions, those with a previous alcohol use disorder, and in those using ayahuasca unsupervised.

Mental health or cognitive side-effects were most often reported by people with previous anxiety issues and lower lifetime use of ayahuasca.

Given that these people had ingested a monoamine oxidase inhibitor (most often harmine or a related compound) and a hallucinogen (DMT), it is not surprising that effects are seen on mental health and perceptions. Both types of drugs have well-known effects on the brain.

It is these very changes in perception and thought that are considered important in these religious events; the psychedelic experience contributing to spiritual growth. But the physical side-effects can also be considered important to the ceremonies, with vomiting and diarrhoea as a type of spiritual cleansing (“purging”).

Is it worth it?

So, do the potential positive effects on mental health and wellbeing outweigh the side-effects of taking ayahuasca?

Despite the reported positive effects of taking ayahuasca, the physical side-effects are very common. These side-effects may be reduced by the proper use of ayahuasca in legitimate ceremonies overseen by experienced religious leaders as part of group worship.

However, there are effective drugs to treat anxiety and depression, and they have a better side-effect profile than ayahuasca. These pharmaceuticals have gone through many years of research and have been tested in randomised controlled trials (the gold standard of clinical testing). Ayahuasca has not yet gone through such rigorous large-scale trials.

There is a resurgence of interest in psychedelics as legitimate clinical options, including LSD and psilocybin, and they are considered to be relatively safe. It may be that future research shows a clinical use for ayahuasca and where it might outperform currently approved medications, but we are not there yet.The Conversation

 

This article is republished from The Conversation under a Creative Commons license. Read the original article.

ShareTweetSendScanShareSharePin3Send

NEWSLETTER SIGN-UP

STAY CONNECTED

TRENDING

One in four people may experience estrangement from a sibling in adulthood, study finds

New study shows how mindfulness can benefit our romantic relationships

The fascinating neuroscience behind dreaming

Cognitive control serves to override the moral default in both honesty and dishonesty

Women are more attracted to men with tougher facial features when facing uncertainty, study finds

New psychology research reveals men’s motives for sending unsolicited dick pics

RECENT

Parents with more difficult childhoods are more likely to spank their children, study finds

Study suggests partisan resentment is bad for your health

The fascinating neuroscience behind dreaming

New study shows how mindfulness can benefit our romantic relationships

New study sheds light on how scarcity is experienced across different sociodemographic groups

One in four people may experience estrangement from a sibling in adulthood, study finds

Cognitive control serves to override the moral default in both honesty and dishonesty

The passage of anti-transgender legislation increases internet searches for “suicide” and “depression”

Currently Playing

Individuals with dark personality traits are less oriented towards long-term mating strategies

Disclosing victim status reduces online dating matches regardless of race or sex

Individuals with dark personality traits are less oriented towards long-term mating strategies

Dark Triad
Longitudinal study examines the effects of adversity on wise reasoning

New study examines the psychological mechanisms underlying Solomon’s paradox

Social Psychology
Engaging in religious practice, even if you don’t believe, may increase your capacity to delay gratification

Engaging in religious practice, even if you don’t believe, may increase your capacity to delay gratification

Cognitive Science
New study sheds light on how three distinct types of first impressions predict subsequent dating outcomes

New study sheds light on how three distinct types of first impressions predict subsequent dating outcomes

Relationships and Sexual Health
A single, moderate dose of psilocybin reduces depressive symptoms for at least two weeks, controlled study finds

A single, moderate dose of psilocybin reduces depressive symptoms for at least two weeks, controlled study finds

Depression
Study identifies factors that influence the link between men’s body esteem and their ability to enjoy their sexuality

Study identifies factors that influence the link between men’s body esteem and their ability to enjoy their sexuality

Mental Health
  • Cognitive Science
  • COVID-19
  • Mental Health
  • Social Psychology
  • Drug Research
  • Conspiracy Theories
  • Meditation
  • Psychology of Religion
  • Aviation Psychology and Human Factors
  • Relationships and Sexual Health
  • Evolutionary Psychology
  • Neuroimaging
  • Psychedelic Drugs
  • Dark Triad
  • Political Psychology

About

PsyPost is a psychology and neuroscience news website dedicated to reporting the latest research on human behavior, cognition, and society. (READ MORE...)

  • Contact us
  • Privacy policy

Subscribe
  • My Account
  • Cognitive Science Research
  • Mental Health Research
  • Social Psychology Research
  • About PsyPost
    • Contact us
  • Privacy policy

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In

Add New Playlist

This website uses cookies. By continuing to use this website you are giving consent to cookies being used.