New research published in Molecular Psychiatry explored the neural and emotional factors that may help victims of childhood maltreatment become resilient to substance use disorder. The study found that people who experienced childhood maltreatment but didn’t develop substance use disorder had better emotional control and a healthier functioning of the endocannabinoid system. These findings may contribute to the development of treatments to prevent substance use disorder in people who have suffered childhood maltreatment.
Childhood maltreatment increases the likelihood of developing substance use disorder in adulthood. However, not everyone who experiences childhood maltreatment develops this disorder, suggesting that some individuals are more resilient to its effects. Previous research has identified several factors that may contribute to this resilience, including emotional control and the functioning of the endocannabinoid system. However, we still don’t fully understand the mechanisms behind these factors.
The endocannabinoid system is a complex signaling system in our bodies that regulates various processes like mood, appetite, pain, and inflammation. Its function can be influenced by different factors such as stress, diet, and genetics. It has also been associated with the development of mental health disorders, including substance use disorders.
“There’s been a lot of focus on addiction as a disease driven by a search for pleasure effects and euphoria, but for many it has more to do with the drugs’ ability to suppress negative feelings, stress sensitivity, anxiety and low mood. Based on this, we and other researchers have had a theory that if affected in childhood, the function of the brain’s distress systems is altered, and that this may contribute to addiction risk in adulthood,” said study author Markus Heilig, a professor and director of the Center for Social and Affective Neuroscience at Linköping University.
To study this further, the research team recruited 101 adults and divided them into four groups based on their experiences of childhood maltreatment and substance use disorder throughout their lives. The groups were as follows: (1) no childhood maltreatment and no substance use disorder; (2) childhood maltreatment but no substance use disorder; (3) no childhood maltreatment but substance use disorder; and (4) childhood maltreatment and substance use disorder.
The study used a combination of questionnaires, physiological recordings, and magnetic resonance imaging (MRI) scans to measure emotional control and endocannabinoid function. The results showed that individuals who experienced childhood maltreatment but didn’t develop substance use disorder had higher levels of endocannabinoid function and better emotional control compared to those who developed substance use disorder.
Specifically, the former group had higher levels of anandamide, a neurotransmitter involved in endocannabinoid function, and they exhibited better emotional control, as shown by lower levels of negative emotions and a greater ability to regulate their emotions in response to stress.
On the other hand, individuals who developed substance use disorder had greater neural activity in the amygdala, a brain region responsible for processing emotions, compared to those who didn’t develop the disorder. This suggests that individuals with substance use disorder may have a heightened sensitivity to emotional stimuli, which increases their risk for developing the disorder.
These findings indicate that endocannabinoid function and emotional control are important factors in the resilience of individuals who experienced childhood maltreatment and didn’t develop substance use disorder. The study provides evidence that these individuals may have a protective mechanism involving higher levels of anandamide and better emotional control. These findings have significant implications for developing interventions aimed at preventing substance use disorder in individuals who have experienced childhood maltreatment.
“Increased activity in certain areas of the brain in the resilient group, which had not developed an addiction despite childhood maltreatment, may be linked to a more adaptive way of reacting to emotional social information. We can see that also in a resting state they show increased communication between the frontal lobes and other parts of the brain, which could indicate that this group has better emotional regulation,” said study author Irene Perini of Linköping University in a news release.
However, the study had some limitations. The sample size of adults involved was relatively small, which may affect how applicable the findings are to the general population. Additionally, the study relied on self-reported measures to assess childhood maltreatment and substance use disorder, which can be biased. Lastly, the study didn’t investigate other potential factors that contribute to resilience, such as social support or coping strategies.
Nevertheless, the results offer valuable insights into the mechanisms that make some individuals resilient to developing substance use disorder after experiencing childhood maltreatment. The findings suggest that endocannabinoid function and emotional control play important roles in this resilience, emphasizing the need for further research to better understand these mechanisms. The study also has important implications for developing interventions to prevent substance use disorder in individuals who have experienced childhood maltreatment.
The study, titled “Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation,” was authored by Irene Perini, Leah M. Mayo, Andrea J. Capusan, Elisabeth R. Paul, Adam Yngve, Robin Kampe, Emelie Gauffin, Raegan Mazurka, and Bijar Ghafouri.
