A study on members of the Royal Netherlands Air Force found that 200 mg of modafinil and 300 mg of caffeine effectively counter the adverse effects of being awake for 17 hours on vigilance. The effect of modafinil seems to...
In a phase II clinical trial, a single dose of psilocybin, combined with SSRI treatment and supportive therapy, showed promising safety and therapeutic outcomes for individuals with treatment-resistant depression. While the results suggest that SSRIs do not inhibit the potential...
A recent study published in the Journal of Psychoactive Drugs analyzed DMT (dimethyltryptamine) experiences shared on Reddit to understand the profound sense of familiarity reported by users. The research found that the sense of familiarity was a distinct aspect of...
A recent study published in the Journal of Psychopharmacology suggests that psilocybin, the active component in "magic mushrooms", can induce lasting neuroplastic changes in the brain, which are associated with improvements in symptoms of depression. The research, which found significant...
A recent meta-analysis published in the Journal of Psychopharmacology indicates that subanesthetic doses of ketamine may provide rapid and sustained relief from anxiety, with effects noticeable within a few hours and lasting up to two weeks. However, the researchers stress...
A new study published in Mindfulness explores the relationship between adverse childhood experiences (ACEs), different components of mindfulness, and cannabis use severity, uncovering that while some facets of mindfulness might help to mitigate the negative impacts of ACEs on cannabis...
An online survey published in the International Journal of Mental Health and Addiction found that after beginning psychedelic use, many adults reduced or stopped their intake of alcohol, antidepressants, and cocaine, but increased their consumption of cannabis and tobacco. The...
An analysis of the UK Biobank data revealed a J-shaped relationship between coffee consumption and the risk of depression and anxiety. Individuals who consumed 2-3 cups of coffee daily had the lowest risk of these mental disorders. However, risks increased...
A recent study in ACS Pharmacology & Translational Science discovered that a temporary spike in stress hormones, specifically corticosterone, plays a central role in reducing anxiety-like behaviors in mice given the psychedelic substance psilocybin. The findings offer crucial insights into...
New research published in the journal Communication Biology shows that psychedelic substances like LSD and ketamine induce "hypersynchrony" in the brain, characterized by highly synchronized high-frequency oscillations across different regions. This unique synchronization, observed in rats, provides insights into altered...
Researchers have found that compounds from the lion's mane mushroom, particularly hericene A, promote nerve cell growth, increase the production of brain-boosting molecules called neurotrophins, and improve memory performance in mice, suggesting their potential as cognitive enhancers. Their findings have...
A recent case study published in Frontiers in Psychology compared the experiences of a near-death experience (NDE) and an experience induced by the psychedelic drug 5-MeO-DMT in a 54-year-old man. While the study found notable similarities such as ego dissolution...
A new study published in the Journal of Psychopharmacology suggests that regular cannabis use alters the connectivity of the executive control network in the brain, a network involved in attention and high-level task performance. Surprisingly, these alterations were found to...
Researchers from Michigan State University's Sleep and Learning Lab have found that while caffeine may help maintain attention in sleep-deprived individuals, it does not reduce errors in complex tasks requiring placekeeping. The study also revealed that napping during an overnight...
Researchers in the United Kingdom recently conducted a study to determine if psychedelic-assisted psychotherapy could be a more cost-effective option than more traditional forms of psychotherapy for those who experience depression. The results suggested that this unique approach could be...