Men experience faster Alzheimer’s progression after brain amyloid buildup
After the start of a buildup of a protein called amyloid-β in the brain, men experience faster increases in certain blood markers of brain changes, more rapid brain shrinkage, and quicker declines in thinking skills compared to women
Regular aerobic exercise shows promise in combating Alzheimer’s disease markers
Regular aerobic exercise reduces disease markers of Alzheimer's in rat brains, a new study finds. Scientists observed less amyloid, tau, and iron accumulation, offering hope for combating this devastating disorder.
Could this inert gas be the key to treating Alzheimer’s disease?
Could an inert gas unlock Alzheimer's treatment? Xenon, used for anesthesia, is showing surprising promise in mice by targeting the brain's immune system and clearing amyloid plaques.
The surprising relationship between vaccinations and Alzheimer’s disease
Could routine shots for tetanus, shingles, and pneumonia offer a surprising shield against Alzheimer’s? Research suggests these common vaccines may significantly lower your risk of developing this devastating brain disease later in life.
Stalled protein processing may underlie Alzheimer’s disease
Mutations in the presenilin-1 gene cause gamma-secretase to stall during protein processing, leading to stable enzyme-substrate complexes. This disruption, rather than amyloid beta buildup, may drive neurodegeneration in Alzheimer’s disease.
Scientists uncover a new mechanical pathway linked to Alzheimer’s disease
Researchers discovered that amyloid precursor protein interacts with talin to maintain synaptic stability. Disruptions in this interaction may lead to Alzheimer’s disease by impairing mechanical signaling, triggering synaptic degeneration, and promoting amyloid plaque formation.
Unsweetened coffee associated with reduced risk of Alzheimer’s and Parkinson’s diseases, study finds
Consuming unsweetened caffeinated coffee is linked to a lower risk of Alzheimer’s, Parkinson’s, and related mortality, while sweetened or artificially sweetened coffee showed no such benefits.
Focused ultrasound shows promise in treating Alzheimer’s by reducing amyloid plaques
A small study found that focused ultrasound safely reduced amyloid plaques and improved neuropsychiatric symptoms in Alzheimer’s patients without medication, offering a promising new treatment approach by targeting the brain’s blood-brain barrier.
Brain health: Immune enzyme linked to toxic tau buildup in Alzheimer’s disease
Researchers found that the immune enzyme TYK2 adds a tag to tau protein, causing toxic buildup in the brain. Blocking TYK2 reduced harmful tau and neuron damage in mice, offering a potential new target for Alzheimer’s treatment.
Alcohol use disorder may exacerbate Alzheimer’s disease through shared genetic pathways
Alzheimer’s disease and alcohol use disorder share similar gene expression changes, including increased inflammation, disrupted brain signaling, and vascular damage, suggesting alcohol use may worsen or accelerate Alzheimer’s progression through shared molecular mechanisms.
Brain health: Knowing two languages might be protective against Alzheimer’s progression
Bilingual individuals with Alzheimer’s disease showed preserved hippocampal volume compared to monolinguals, suggesting bilingualism may provide brain maintenance benefits.
Nicotinamide trial for Alzheimer’s disease shows no clear benefit in reducing tau proteins
A high dose of nicotinamide, tested as a treatment for early-stage Alzheimer’s, showed no significant impact on reducing harmful tau proteins in the brain.
Could a rare gene delay Alzheimer’s? APOE3 Christchurch inspires hope for future therapies
A rare genetic variant, APOE3 Christchurch, delays Alzheimer's onset by years in high-risk individuals, offering insights into disease resilience. This discovery could guide new treatments targeting similar protective pathways for Alzheimer’s prevention and therapy.
Neuroscientists just turned a major Alzheimer’s theory on its head
New research suggests Alzheimer's drugs may improve cognition by increasing Aβ42 levels rather than just reducing plaques, challenging the amyloid cascade hypothesis and pointing to new therapeutic strategies focused on restoring soluble Aβ42 to maintain brain health.
MIND diet slows cognitive decline in older adults, but effects vary by race
The MIND diet slows cognitive decline in older adults, with Black participants requiring stricter adherence for benefits. Racial and gender differences suggest broader social, lifestyle, and biological factors influence the diet's effectiveness.
