Alzheimer's Disease

When the brain's cellular recycling system breaks down in Alzheimer's disease, damaged mitochondria pile up inside nerve fibers. Researchers have now identified these clusters as "mitochondrial plaques," revealing a new pathological feature that could unlock novel treatments.

A new meta-analysis reveals that common lithium treatments do not slow memory loss in older adults with Alzheimer’s disease or mild cognitive impairment, despite previous laboratory research suggesting the mineral might have neuroprotective benefits.

The diabetes and weight-loss medication semaglutide can accelerate the resolution of brain inflammation. By mapping cellular changes in mice, researchers discovered how the drug engages specific brainstem neurons to protect against pathways associated with cognitive decline.

The age a woman goes through menopause could predict her long-term neurological health. A new study links early menopause to faster cognitive decline, suggesting the transition is a vital window for protecting the brain.

Standard genetic tests for Alzheimer's often fail in non-European populations. A new study shows that blending global genetic data creates a highly accurate tool that predicts both Alzheimer's risk and underlying brain damage across diverse ancestral groups.

Alzheimer's disease and frontotemporal dementia share overlapping symptoms, making early diagnosis difficult. A new study reveals that tiny brain-derived vesicles carry distinct genetic markers for each condition, offering a potential new avenue for early detection.

A new study suggests that regular treadmill running can fully reverse memory loss and reduce toxic brain plaques in mice with Alzheimer’s disease. The benefits appear linked to a specific cellular pathway that boosts brain health.

A new study reveals that two different inflammatory proteins in the blood signal separate types of brain damage. Both distinct pathways ultimately converge to fuel Alzheimer's-related tau tangles, brain shrinkage, and memory decline in older adults.

Professions requiring constant spatial navigation physically reshape the hippocampus, the brain region Alzheimer’s attacks first. By routinely building mental maps, individuals may develop a cognitive reserve that delays the onset of severe memory loss.

New research reveals that physical social isolation harms the aging brain independently of subjective feelings of loneliness. Simulated public health interventions show that reconnecting isolated older adults can directly protect against cognitive decline.

A 12-week program requiring older adults to read out loud, write by hand, and solve basic math problems for 30 minutes a day resulted in measurable improvements on cognitive tests.

People with Down syndrome face an elevated risk of developing Alzheimer's disease. A recent study indicates that simple blood tests can accurately detect early brain changes, paving the way for easier diagnosis and inclusive clinical trials.

A recent review in Molecular and Cellular Neuroscience suggests that popular weight-loss and diabetes drugs might help clear brain proteins associated with Alzheimer's disease. While animal studies show promise, human data remains limited.

By genetically enhancing a specific protein in mice, scientists successfully reduced the toxic tau tangles associated with Alzheimer’s disease. The study offers new insights into how the brain defends itself against severe neurodegenerative damage.