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Home Exclusive Mental Health ADHD

Shifting genetic tides: How early language skills forecast ADHD and literacy outcomes

by Eric W. Dolan
March 5, 2024
in ADHD, Developmental Psychology
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Recent research has provided new insights into the developmental trajectory of children’s language abilities. The study, published in Biological Psychiatry, uncovered a shift in the genetic relationship between vocabulary size and ADHD risk/symptoms from infancy to toddlerhood.

Early language development serves as a crucial predictor of children’s subsequent language, reading, and learning skills. It’s also closely linked with neurodevelopmental conditions such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD).

Typically, children start speaking their first words between 10 and 15 months of age, and by the age of two, they may know between 100 to 600 words. However, the pace and extent of language development vary significantly among children, a phenomenon that can partly be attributed to genetic differences.

The researchers conducted a genome-wide meta-analysis study (GWAS), a sophisticated approach that allowed them to examine the entire genome to identify genetic variants associated with vocabulary development. This analysis was performed on a large and diverse cohort of 17,298 children who were English-, Danish-, or Dutch-speaking, encompassing a broad linguistic and cultural spectrum.

Parents played a crucial role in this study by reporting on their children’s language abilities. They provided information on the number of words their children could say and understand from a predetermined list, a method that has been widely used in language development research for its practicality and effectiveness.

This parental reporting offered a valuable snapshot of the child’s active and receptive vocabulary at critical developmental milestones: infants (15-18 months) and toddlers (24-38 months). The data collected included both the number of words spoken and understood by the children, although for toddlers, more emphasis was placed on understanding due to its increasing complexity and significance in language development.

A particularly compelling aspect of the study’s findings was the dynamic nature of the genetic influences on vocabulary size as children grow. In infants, a larger vocabulary size was found to be genetically associated with an increased risk for ADHD and more ADHD symptoms. This suggests that the genetic factors contributing to a larger vocabulary in infancy may overlap with those predisposing children to ADHD, potentially reflecting an early expressive language proficiency or a heightened drive to communicate.

But this relationship reverses in toddlerhood. For toddlers, a smaller vocabulary size was associated with more ADHD symptoms, indicating that as children transition into more advanced stages of language development, those with a higher genetic risk for ADHD might face challenges in expanding their vocabulary. This shift from infancy to toddlerhood highlights the evolving influence of genetics on language development and its interplay with neurodevelopmental conditions.

Moreover, the study found that both infant and toddler vocabulary sizes were genetically linked to later-life literacy skills, such as spelling. This connection was consistent across age groups, suggesting a stable genetic component that influences both early language development and future literacy abilities.

However, the association with general cognitive abilities, including intelligence and educational attainment, emerged only in toddlerhood. This distinction underscores the developmental progression from simply acquiring vocabulary to utilizing language skills for learning and cognitive development. Toddlers, having achieved a certain level of language fluency, engage in “speaking to learn,” which involves more complex cognitive processing and is influenced by genetic factors associated with broader cognitive abilities.

“Genetic influences underlying vocabulary size rapidly change across less than two years during infancy and toddlerhood. Adopting a developmental perspective, our findings provide a better understanding of early speech- and language-related aetiological processes in health and disorder,” said senior researcher Beate St Pourcain, lead scientist on the study.

First author Ellen Verhoef added: “This research indicates the relevance of vocabulary size assessed during the first few years in life for future behavior and cognition, emphasising the need for more data collection efforts during infancy and toddlerhood.”

Despite its groundbreaking insights, the study acknowledges certain limitations, including the focus on children of European descent and the reliance on parental reports for vocabulary assessment. These factors underscore the need for further research across diverse populations and methodologies. The study’s findings pave the way for future investigations into the dynamic changes in genetic influences on early language development and their implications for educational practices and interventions for children with developmental challenges.

The study, “Genome-wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits,” was authored by Ellen Verhoef, Andrea G. Allegrini, Philip R. Jansen, Katherine Lange, Carol A. Wang, Angela T. Morgan, Tarunveer S. Ahluwalia, Christos Symeonides, EAGLE Working Group, Else Eising, Marie-Christine Franken, Elina Hypponen, Toby Mansell, Mitchell Olislagers, Emina Omerovic, Kaili Rimfeld, Fenja Schlag, Saskia Selzam, Chin Yang Shapland, Henning Tiemeier, Andrew J.O. Whitehouse, Richard Saffery, Klaus Bønnelykke, Sheena Reilly, Craig E. Pennell, Melissa Wake, Charlotte A.M. Cecil, Robert Plomin, Simon E. Fisher, and Beate St. Pourcain.

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