Ketamine

Ketamine infusion induces feelings of awe, which may mediate its antidepressant effects. Stronger awe experiences were linked to greater, longer-lasting depression symptom improvements, independent of dissociative symptoms

Researchers found that ketamine reduces "giving up" behavior in zebrafish by altering astrocyte activity, suggesting its antidepressant effects involve non-neuronal brain cells and promoting resilience against futility-induced passivity.

A study found that ketamine, which causes dissociation, did not increase emotional suppression in PTSD patients. Instead, it decreased brain connectivity involved in emotion regulation.

Researchers found that ketamine blurs the brain’s ability to distinguish between self- and other-produced touch, particularly in a brain area involved in social processing.

Ketamine was linked to a sustained reduction in suicidal ideation in depressed patients, with effects lasting up to 270 days, according to new research using electronic health records.

A new study suggests that the subjective experiences of psychedelics like ketamine and psilocybin modestly contribute to their therapeutic effects, particularly for depression and substance use disorder.

Researchers found that ketamine increases redundant brain activity, especially in the alpha frequency band, leading to dissociative experiences. Portable EEG devices effectively tracked these changes, offering insights into how ketamine alters brain function during rest and tasks.

New research explores how music could influence patient experiences during intranasal ketamine therapy for treatment-resistant depression, potentially opening doors to more effective and comfortable treatment protocols.

New research explores an unexpected effect of ketamine on individuals with treatment-resistant depression, revealing potential implications for its use beyond traditional antidepressant applications.

(R)-ketamine restores neuronal activity in the anterior insular cortex and improves social memory in mice affected by chronic social isolation, according to new research.

A new study has found no significant link between participation in ketamine clinical trials and subsequent symptoms of ketamine abuse.

A study found ketamine's rapid antidepressant effects in rats hinge on activating the brain's opioid system, particularly β-endorphin in the prefrontal cortex. Blocking this pathway negates ketamine's benefits, unveiling potential targets for new depression treatments.

Northwestern University researchers have uncovered how ketamine delivers rapid and prolonged depression relief by activating new neurons for immediate effects and increasing their production for lasting benefits. This breakthrough could lead to safer, ketamine-inspired antidepressants.

SSRIs like escitalopram may boost brain plasticity, potentially aiding in depression treatment by enhancing neural adaptability and communication. Novel treatments like intranasal esketamine and psychedelics target different brain receptors, suggesting diverse mechanisms of action. Understanding these processes is crucial for...

A multi-center U.S. study suggests ketamine significantly improves severe, treatment-resistant depression, offering hope for rapid, effective therapy.