Cannabis

A 31-year-old man amputated his ears and penis while in a psychotic state after consuming cannabis and kratom. The case report underscores the rare but severe psychiatric risks of these substances.

A study of adults with anxiety found that cannabis products with higher cannabidiol (CBD) content tended to improve mood and sleep regardless of inflammation, while the effects of THC-dominant cannabis varied with participants’ baseline inflammatory status.

A new clinical trial has found that a single dose of cannabidiol can reduce alcohol craving and dampen activity in a brain region tied to reward. The findings point to CBD’s potential as a treatment option for alcohol use disorder.

Does cannabis help or harm memory in older age? A new study in rats suggests the answer is complex. Researchers found THC’s effects depended on sex and delivery method, improving working memory in some cases while impairing it in others.

A new study shows that only one form of hexahydrocannabinol—9(R)-HHC—produces behavioral effects similar to THC in mice, raising concerns about its psychoactive potential. The findings highlight key differences between HHC variants commonly sold as cannabis alternatives.

While many people use cannabis to help them sleep, a new study reveals a surprising outcome. Researchers found a single dose of a medicinal cannabis oil actually decreased total sleep time and significantly suppressed the REM sleep (or dreaming) phase.

Nineteen patients with drug-resistant epilepsy experienced seizure freedom after cannabis oil treatment, with a median seizure-free duration of 245 days. Five remained seizure-free for over a year, and most reported improved quality of life and reduced seizure frequency.

Researchers have discovered that frequent cannabis users show reduced spontaneous brain activity in the motor cortex, and this neural suppression is tied to cannabis use severity and response speed, even though overall task performance remained comparable to non-users.

Cannabis products promise custom experiences based on compound profiles, but the science behind these claims remains limited. While ideas like the “entourage effect” are popular, research on how cannabis compounds interact in humans is still in its early stages.

In a study using an Alzheimer’s disease mouse model, researchers found that cannabidiol reduced memory loss and brain abnormalities. The compound worked by enhancing the function of glycine receptors, which help regulate neuronal activity in the brain's memory center.

Cannabidiol appears to improve social memory in mice, according to new research in Psychopharmacology. The study shows that CBD enhances the ability to remember food-related information from peers by increasing acetylcholine activity in the basal forebrain.

Researchers in Switzerland have completed the first randomized trial comparing legal and illegal cannabis use. The study suggests that public health-oriented cannabis access may help reduce misuse, particularly among people with more complex patterns of drug use.

A new study suggests daily cannabis use may be linked to chronic inflammation. Researchers found that young adults who used cannabis frequently had higher levels of suPAR, an inflammatory marker, while occasional users did not.

In a study of young people with cannabis use disorder, N-acetylcysteine failed to outperform a placebo in reducing cannabis use, suggesting that the supplement may not be effective unless combined with more intensive behavioral interventions like contingency management.

Young women who use cannabis may face an elevated risk of binge eating, a new study finds. The link remained even after controlling for depressive symptoms and other factors.