A recent scientific study has uncovered an intriguing connection between the use of psilocybin, the psychoactive compound found in certain "magic" mushrooms, and reduced overtime work among full-time employees. While the study's findings aren't conclusive proof of causation, they shed...
In a phase II clinical trial, a single dose of psilocybin, combined with SSRI treatment and supportive therapy, showed promising safety and therapeutic outcomes for individuals with treatment-resistant depression. While the results suggest that SSRIs do not inhibit the potential...
A recent study published in the Journal of Psychoactive Drugs analyzed DMT (dimethyltryptamine) experiences shared on Reddit to understand the profound sense of familiarity reported by users. The research found that the sense of familiarity was a distinct aspect of...
A recent study published in the Journal of Psychopharmacology suggests that psilocybin, the active component in "magic mushrooms", can induce lasting neuroplastic changes in the brain, which are associated with improvements in symptoms of depression. The research, which found significant...
An online survey published in the International Journal of Mental Health and Addiction found that after beginning psychedelic use, many adults reduced or stopped their intake of alcohol, antidepressants, and cocaine, but increased their consumption of cannabis and tobacco. The...
A recent study in ACS Pharmacology & Translational Science discovered that a temporary spike in stress hormones, specifically corticosterone, plays a central role in reducing anxiety-like behaviors in mice given the psychedelic substance psilocybin. The findings offer crucial insights into...
New research published in the journal Communication Biology shows that psychedelic substances like LSD and ketamine induce "hypersynchrony" in the brain, characterized by highly synchronized high-frequency oscillations across different regions. This unique synchronization, observed in rats, provides insights into altered...
A recent case study published in Frontiers in Psychology compared the experiences of a near-death experience (NDE) and an experience induced by the psychedelic drug 5-MeO-DMT in a 54-year-old man. While the study found notable similarities such as ego dissolution...
Researchers in the United Kingdom recently conducted a study to determine if psychedelic-assisted psychotherapy could be a more cost-effective option than more traditional forms of psychotherapy for those who experience depression. The results suggested that this unique approach could be...
A new study found that giving mice 5-MeO-DMT, a short-acting psychedelic, leads to a long-lasting increase of dendritic spine density in the medial frontal cortex region of their brains, potentially countering the neural changes produced by depression. The psychological effects...
A recent study published in Frontiers in Psychology explores the potential positive impact of mindfulness meditation and psychedelic use on leadership development among business managers. The research highlights how both practices contribute to enhanced well-being, awareness, creativity, and interpersonal attitudes.
Mike Jay's "Psychonauts: Drugs and the Making of the Modern Mind" investigates the history and influence of psychoactive substances, shedding light on how the human relationship with these substances has evolved over time. With a particular focus on the impact...
Psilocybin has antidepressant-like effects and can improve cognitive function in a rat model of depression induced by chronic stress, according to new research published in Psychedelic Medicine. The findings provide new insights into the potential therapeutic applications of psychedelic substances...
New research provides unique insights into how different drugs, including psychedelic substances, engage with the brain's neurotransmitter landscape to produce their effects on brain activity. The findings, published in Science Advances, indicate that psychoactive drugs interact with the brain's neurotransmitter...
An open label study of a group of individuals suffering from posttraumatic stress disorder (PTSD) who also reported suffering chronic pain showed that MDMA-assisted therapy led to significant reduction in pain intensity and pain-related disability in participants with highest levels...