Psychedelic Drugs

A new study found that giving mice 5-MeO-DMT, a short-acting psychedelic, leads to a long-lasting increase of dendritic spine density in the medial frontal cortex region of their brains, potentially countering the neural changes produced by depression. The psychological effects...

A recent study published in Frontiers in Psychology explores the potential positive impact of mindfulness meditation and psychedelic use on leadership development among business managers. The research highlights how both practices contribute to enhanced well-being, awareness, creativity, and interpersonal attitudes.

Mike Jay's "Psychonauts: Drugs and the Making of the Modern Mind" investigates the history and influence of psychoactive substances, shedding light on how the human relationship with these substances has evolved over time. With a particular focus on the impact...

Psilocybin has antidepressant-like effects and can improve cognitive function in a rat model of depression induced by chronic stress, according to new research published in Psychedelic Medicine. The findings provide new insights into the potential therapeutic applications of psychedelic substances...

New research provides unique insights into how different drugs, including psychedelic substances, engage with the brain's neurotransmitter landscape to produce their effects on brain activity. The findings, published in Science Advances, indicate that psychoactive drugs interact with the brain's neurotransmitter...

An open label study of a group of individuals suffering from posttraumatic stress disorder (PTSD) who also reported suffering chronic pain showed that MDMA-assisted therapy led to significant reduction in pain intensity and pain-related disability in participants with highest levels...

A study published in the Journal of Affective Disorders reveals that psilocybin-assisted therapy reduces experiential avoidance, leading to improved well-being and decreased depression, anxiety, and suicidal thoughts in depressed patients. The research highlights the significance of experiential avoidance as a...

A psychedelic helpline has been shown in new research to effectively mitigate psychological risks by providing peer support and harm reduction to individuals experiencing difficulties during psychedelic experiences. The helpline significantly contributed to de-escalating distress for callers and prevented potential...

A new study suggests that psilocybin-assisted group therapy is a promising approach for cancer patients dealing with depressive symptoms. The research, which appears in the Journal of Pain and Symptom Management, provides initial evidence of the safety, feasibility, and possible...

The most comprehensive survey on psychedelic drug use to date has provided valuable insights into the frequency, reasons, and experiences associated with psychedelic use in Canada. The extensive findings, published in the journal Psychedelic Medicine, have the potential to inform...

Incorporating the psychedelic drug psilocybin into psychotherapy shows promise in the treatment of depression, according to new research published in the Journal of Psychopharmacology. But the study also highlights the difficulty of implementing effective blinding procedures to prevent expectancy effects...

New research provides evidence that LSD alters the effects of brain stimulation and produces different and potentially larger changes in brain activity. The preliminary findings suggest that psychedelic drugs and brain stimulation may have a synergistic effect that could be...

A new study suggests that the use of certain antidepressants, specifically SSRIs and SNRIs, may weaken the acute subjective effects of psilocybin in some individuals. The findings, which appear in the Journal of Psychopharmacology, indicate that this dampening effect on...

Blocking the subjective psychedelic effects of psilocybin does not appear to interfere with the substance's ability to potentially help with obsessive behaviors, according to new research published in Translational Psychiatry. The findings contribute to the growing body of research on...

A new study has found that classic psychedelic use is associated with increased psychological distress among unemployed individuals, according to new research published in the Journal of Psychedelic Studies.