Alzheimer's Disease

Scientists found that air pollutants trigger a chemical change (S-nitrosylation) in a vital brain protein (CRTC1), disrupting memory-related gene activity. Blocking this process partially restored memory in Alzheimer’s mice and could lead to new treatments.

Using a new brain mapping method, researchers found that specific memory cells in the hippocampus are highly susceptible to protein buildup linked to Alzheimer's disease, while other brain cells are more resistant.

After the start of a buildup of a protein called amyloid-β in the brain, men experience faster increases in certain blood markers of brain changes, more rapid brain shrinkage, and quicker declines in thinking skills compared to women

Regular aerobic exercise reduces disease markers of Alzheimer's in rat brains, a new study finds. Scientists observed less amyloid, tau, and iron accumulation, offering hope for combating this devastating disorder.

Could an inert gas unlock Alzheimer's treatment? Xenon, used for anesthesia, is showing surprising promise in mice by targeting the brain's immune system and clearing amyloid plaques.

Could routine shots for tetanus, shingles, and pneumonia offer a surprising shield against Alzheimer’s? Research suggests these common vaccines may significantly lower your risk of developing this devastating brain disease later in life.

Mutations in the presenilin-1 gene cause gamma-secretase to stall during protein processing, leading to stable enzyme-substrate complexes. This disruption, rather than amyloid beta buildup, may drive neurodegeneration in Alzheimer’s disease.

Consuming unsweetened caffeinated coffee is linked to a lower risk of Alzheimer’s, Parkinson’s, and related mortality, while sweetened or artificially sweetened coffee showed no such benefits.

A small study found that focused ultrasound safely reduced amyloid plaques and improved neuropsychiatric symptoms in Alzheimer’s patients without medication, offering a promising new treatment approach by targeting the brain’s blood-brain barrier.

Researchers found that the immune enzyme TYK2 adds a tag to tau protein, causing toxic buildup in the brain. Blocking TYK2 reduced harmful tau and neuron damage in mice, offering a potential new target for Alzheimer’s treatment.

Alzheimer’s disease and alcohol use disorder share similar gene expression changes, including increased inflammation, disrupted brain signaling, and vascular damage, suggesting alcohol use may worsen or accelerate Alzheimer’s progression through shared molecular mechanisms.

Bilingual individuals with Alzheimer’s disease showed preserved hippocampal volume compared to monolinguals, suggesting bilingualism may provide brain maintenance benefits.

A high dose of nicotinamide, tested as a treatment for early-stage Alzheimer’s, showed no significant impact on reducing harmful tau proteins in the brain.

A rare genetic variant, APOE3 Christchurch, delays Alzheimer's onset by years in high-risk individuals, offering insights into disease resilience. This discovery could guide new treatments targeting similar protective pathways for Alzheimer’s prevention and therapy.