Depression

Sexual minority adults not only report higher rates of depression but also show distinct biological reactions to it. New findings indicate these mental health struggles are accompanied by increased systemic inflammation.

A massive new analysis challenges the idea that depression trends are the same for everyone. The results also highlight a specific turning point in the last decade where symptoms began to surge.

Researchers found that a single dose of psilocybin alters the electrical properties of brain cells for months. This functional plasticity, rather than structural growth, may explain why psychedelic therapy offers enduring relief from depression.

A comprehensive analysis maps where physical shrinkage and electrical dysfunction converge in the depressed brain, linking these overlapping abnormalities to genes involved in early neural development.

A new study of 15,000 people reveals atypical depression is a distinct biological subtype. Researchers found specific genetic risks and evidence that standard antidepressants may be less effective for this group.

Depression may make unfair offers seem fairer, but only if you perceive yourself as having high social status. New research explores how socioeconomic status moderates the cognitive distortions associated with depression in financial decision-making.

A recent study suggests MDMA-assisted therapy may provide lasting relief for major depressive disorder. Participants maintained significant symptom reductions several months after treatment concluded.

A large Finnish study following 114,000 young people found that living near busy roads increases the risk of depression and anxiety. The risk starts rising at noise levels commonly found in cities, independent of air pollution.

A new study finds that while antidepressants often cause yawning, an increase in frequency might mean the drugs aren't working. This physical marker could help doctors better monitor patient progress.

Why do some people with depression seek help while others don’t? A new BMJ Mental Health study suggests the answer lies in “illness beliefs”—specifically, recognizing the condition and trusting that treatment works.

A new study suggests a simple EEG test can predict sexual side effects from antidepressants with 87% accuracy. Researchers found that patients with naturally high serotonin activity are significantly more likely to experience orgasmic dysfunction.

Researchers have identified specific biological pathways, including neural activity and inflammation, that connect mental health conditions to cardiovascular disease. The findings suggest that managing stress is vital for heart health prevention.

A large clinical trial conducted by the Department of Veterans Affairs suggests that analyzing a patient’s DNA can help providers choose antidepressants that are safer and more effective, leading to faster symptom relief.

Researchers have determined that an increase of ten extreme heat days is associated with a 6.2 percent increase in the odds of reporting mental health conditions after controlling for demographic factors.

A new study suggests that training the brain to recall positive memories can lower daytime cortisol levels. The findings indicate that modifying memory bias may offer a way to build physiological resilience against stress.