Psilocybin

A 41-year-old woman with Long-COVID reportedly experienced significant symptom relief after using psilocybin and MDMA, but the effectiveness and safety of these psychedelics for Long-COVID remain uncertain and require further research.

A new study found that psilocybin improves body weight maintenance and cognitive flexibility in female rats modeled for anorexia nervosa, mainly through serotonin 5-HT1A receptor activity. These effects suggest potential therapeutic benefits for treating cognitive inflexibility in anorexia.

A pilot study found that psilocybin administered in a group retreat setting led to enhanced psychological flexibility, improved self-compassion, and reduced cognitive fusion, suggesting potential therapeutic benefits for mental health.

Combining psilocybin with meditation enhances brain connectivity and information flow, according to new research. This was evidenced by increased centrality in brain networks, suggesting improved cognitive integration.

New research shows psilocybin causes anxiety in mice through mechanisms distinct from its psychedelic effects. While ketanserin reduces psilocybin’s psychedelic impact by targeting the 5-HT2A receptor, it does not alleviate the anxiety, suggesting different pathways are involved.

New research suggests psilocybin-assisted therapy can lead to both short-term and long-term negative effects, including emotional and cognitive instability, difficulties in therapist-client relationships, and challenges integrating therapy insights, indicating the need for cautious application and further research into its psychological...

Researchers at the University of Michigan found that psilocybin significantly reduced chronic touch-related pain in rats without affecting heat-related pain. The pain relief outlasted the drug's presence in the body, suggesting a central brain mechanism could be responsible.

Researchers recently explored the potential of psilocybin, a compound from magic mushrooms, to combat diabetes. The findings suggest that psilocybin might protect pancreatic β-cells from damage.

A pivotal study explored how patient expectations affect psilocybin therapy outcomes, discovering no significant impact. Interestingly, suggestible individuals showed enhanced benefits, suggesting a unique interplay between mindset and psychedelic therapy effectiveness.

A new study provides evidence that mushroom extract containing psilocybin may offer superior therapeutic effects for psychiatric disorders compared to synthetic psilocybin, suggesting an "entourage effect" of additional compounds enhancing treatment outcomes.

Psilocybin therapy alters brain activity in patients with alcohol use disorder, according to new research, increasing activity in areas associated with emotional regulation and reducing activity in regions linked to craving.

A groundbreaking study sheds light on psilocybin therapy's success in treating depression, highlighting the crucial roles of mystical experiences and ego dissolution, enhanced by music, in surpassing traditional treatments. The findings were published in the International Journal of Mental Health...

A study revealed psilocybin diminishes the amygdala response to angry faces, potentially impacting emotion processing. This discovery underscores its potential for treating conditions like depression and anxiety, highlighting the profound effects of psychedelics on the brain.

A recent study explores psilocybin's effects on larval zebrafish, revealing it enhances exploratory behavior and buffers stress-induced activity changes, offering insights into psychedelic compounds' potential in mental health treatment.

Can groundbreaking treatments for depression and other psychiatric conditions come from substances once considered purely recreational or even taboo? A recent study by researchers at Johns Hopkins Medicine suggests the answer may be yes.