Psilocybin

In a phase II clinical trial, a single dose of psilocybin, combined with SSRI treatment and supportive therapy, showed promising safety and therapeutic outcomes for individuals with treatment-resistant depression. While the results suggest that SSRIs do not inhibit the potential...

A recent study published in the Journal of Psychopharmacology suggests that psilocybin, the active component in "magic mushrooms", can induce lasting neuroplastic changes in the brain, which are associated with improvements in symptoms of depression. The research, which found significant...

A recent study in ACS Pharmacology & Translational Science discovered that a temporary spike in stress hormones, specifically corticosterone, plays a central role in reducing anxiety-like behaviors in mice given the psychedelic substance psilocybin. The findings offer crucial insights into...

Researchers in the United Kingdom recently conducted a study to determine if psychedelic-assisted psychotherapy could be a more cost-effective option than more traditional forms of psychotherapy for those who experience depression. The results suggested that this unique approach could be...

Psilocybin has antidepressant-like effects and can improve cognitive function in a rat model of depression induced by chronic stress, according to new research published in Psychedelic Medicine. The findings provide new insights into the potential therapeutic applications of psychedelic substances...

A study published in the Journal of Affective Disorders reveals that psilocybin-assisted therapy reduces experiential avoidance, leading to improved well-being and decreased depression, anxiety, and suicidal thoughts in depressed patients. The research highlights the significance of experiential avoidance as a...

A new study suggests that psilocybin-assisted group therapy is a promising approach for cancer patients dealing with depressive symptoms. The research, which appears in the Journal of Pain and Symptom Management, provides initial evidence of the safety, feasibility, and possible...

Incorporating the psychedelic drug psilocybin into psychotherapy shows promise in the treatment of depression, according to new research published in the Journal of Psychopharmacology. But the study also highlights the difficulty of implementing effective blinding procedures to prevent expectancy effects...

A new study suggests that the use of certain antidepressants, specifically SSRIs and SNRIs, may weaken the acute subjective effects of psilocybin in some individuals. The findings, which appear in the Journal of Psychopharmacology, indicate that this dampening effect on...

Blocking the subjective psychedelic effects of psilocybin does not appear to interfere with the substance's ability to potentially help with obsessive behaviors, according to new research published in Translational Psychiatry. The findings contribute to the growing body of research on...

New research published in iScience provides unique insights into how psilocybin alters brain activity during psychedelic experiences. The findings suggest that while the overall activity of the brain becomes more chaotic during the psychedelic state, the brain's ability to maintain...

People who use psychedelic substances in an attempt to self-treat their mental health tend to report mild-to-moderate positive outcomes, according to new research published in the Journal of Psychopharmacology. But there were more negative effects reported by these individuals than...

The results from the first randomized, double-blind, placebo-controlled study to systematically investigate the effects of psilocybin in cluster headache has been published in the scientific journal Headache. The initial study provides useful information for creating bigger and more conclusive studies...

The use of psilocybin, a hallucinogenic substance found in some "magic" mushrooms, has stronger connection to how people feel about nature compared to the use of other psychedelic drugs, according to new research published in the Journal of Psychopharmacology.